103898-11-9 Tert-Butyl N,N-Bis(2-Hydroxyethyl)Carbamate

Drug Discovery: Tert-Butyl N,N-Bis(2-Hydroxyethyl)Carbamate is commonly used as a protecting group in drug discovery. It reacts with functional groups such as hydroxyls and amines in drug molecules, forming stable tert-butoxycarbonyl (Boc) protected derivatives. This protection allows for stable synthesis and purification, and the Boc group can be removed under suitable conditions to expose the original functional group for further reactions or biological activity studies. Therefore, it has potential applications in drug synthesis, drug modification, and controlled drug release.

Peptide Synthesis: Tert-Butyl N,N-Bis(2-Hydroxyethyl)Carbamate also finds use as a linker in peptide synthesis. It can react with the carboxyl group of amino acids, forming stable amide bonds to connect two or more amino acids, creating peptide chains with specific sequences and structures. This linker is widely used in solid-phase peptide synthesis, liquid-phase peptide synthesis, and other methods.

Biochemical Research: Due to its biodegradable nature, Tert-Butyl N,N-Bis(2-Hydroxyethyl)Carbamate is also used as a tool in biochemical research. For example, it can be employed as a linker in the synthesis of antibody-drug conjugates (ADCs), connecting drugs to antibodies for targeted delivery and release. Additionally, it can be used to study protein-protein and protein-ligand interactions, as well as protein localization and function within cells.