109425-51-6 Fmoc-L-His(Trt)-OH

109425-51-6  Fmoc-L-His(Trt)-OH belongs to L-histidine derivatives, which is an essential human amino acid, compared with other amino acids, in addition to some common chemical reactions L-histidine due to its right side chain imidazole group and diazobenzenesulfonic acid can form a brownish-red compound, that is, Pauly (Pauly) reaction.

109425-51-6  Fmoc-L-His(Trt)-OH also can be one of Triptorelin Acetate Intermediates.Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction. It is also used as therapy in cases of gender dysphoria.

During the treatment of prostate cancer it does cause a surge of testosterone (an initial uplevel of testosterone levels), known as a flare effect. In men a reduction of serum testosterone levels into the range normally seen after surgical castration occurs approximately two to four weeks after initiation of therapy. In contrast, gonadotropin-releasing hormone antagonists do not cause a surge, but a sudden reduction of testosterone levels.