167393-62-6 Fmoc-L-Lys(Mtt)-OH

Solid-Phase Peptide Synthesis (SPPS): In SPPS, peptides are synthesized on a solid support, typically a resin. 167393-62-6 Fmoc-L-Lys(Mtt)-OH is used as one of the building blocks for peptide synthesis. The Fmoc (9-fluorenylmethoxycarbonyl) group is a protecting group that is commonly used in SPPS to protect the amino group of amino acids, preventing unwanted side reactions during peptide bond formation. The Mtt (4-methyltrityl) group is another protecting group, often used to protect the epsilon amino group of lysine residues. This allows for selective deprotection and coupling reactions during peptide elongation.

Selective Deprotection: 167393-62-6 Fmoc-L-Lys(Mtt)-OH can be selectively removed under mild conditions, typically using an acid such as trifluoroacetic acid (TFA). This exposes the amino group of lysine, allowing it to participate in peptide bond formation with the next amino acid in the sequence.

Orthogonal Protection Strategy: 167393-62-6 Fmoc-L-Lys(Mtt)-OH is often used in conjunction with other Fmoc-protected amino acids with different protecting groups to allow for the synthesis of complex peptides with multiple protected functional groups. This strategy involves selectively deprotecting and coupling specific amino acids in a predetermined sequence to build the desired peptide chain.

Peptide Modification: 167393-62-6  Fmoc-L-Lys(Mtt)-OH can also serve as a handle for further modifications. After peptide synthesis, the Mtt group can be selectively removed, leaving a free amino group at the lysine residue for conjugation with other molecules or for further functionalization.