22254-24-6 8-Isopropylatropinium bromide

Ipratropium bromide is also known as Haizhupanidine, isopropyl atropine, isopropyl scopolamine, isopropyl atropine, ipratropine bromide, isopropyl atropine bromide, ipratropine bromide, ipratropium bromide, and ipratropium bromide. It is a white crystalline powder with bitter taste. Melting point 232℃-233℃. Soluble in water, slightly soluble in ethanol, insoluble in other organic solvents. Chemical name: Brominated α-(hydroxymethyl) -phenylacetic acid - 8-methyl-8-isopropyl - azocyclic [3,2,1] -3-octyl ester. It is an anticholinergic drug, which has a strong relaxation effect on bronchial smooth muscle and antiasthmatic effect on chronic obstructive pulmonary disease. Its effect is obvious, quick effect and long duration. Ipratropium bromide also controls the secretion of mucus glands and improves ciliary movement, thus reducing sputum obstruction to improve ventilation. Meanwhile, the reduction of sputum also alleviates bronchospasm caused by bronchial irritation. For the prevention and treatment of bronchial asthma and asthmatic chronic bronchitis, especially for patients who cannot tolerate the use of β-agonist muscle tremor, tachycardia. This product can be used in combination with beta-agonists to enhance the efficacy of each other, such as in combination with finoterol to form an aerosol (BERODU -- AL) for asthma, chronic bronchitis and emphysema. Compared with β-adrenergic receptor stimulants (e.g., isopropyl epinephrine), this product has less cardiovascular side effects, and compared with β2-receptor stimulants (e.g., Suquanling), this product has a stronger regulatory effect on phlegm volume.
Spray inhalation. 40 ~ 80μg once, 2 ~ 4 times a day. When using, first remove the cover shell cap, put the cover shell cross eye on the nozzle, turn the bottle upside down, contain the cover shell in the mouth, aim at the throat, suction the gas at the same time, press the nozzle on the valve, inhale the liquid, hold your breath for a moment. Repeat the above snap once if necessary. Aerosol: 0.025% solution. Tablet: 10mg/tablet.
Severe anticholinergic poisoning can be treated with cholinesterase inhibitors.
The adverse reactions of ipratropium bromide are similar to atropine, which can cause palpitation, headache, dizziness, nervousness, nausea, vomiting, gastrointestinal pain, tremor, blurred vision, dry mouth, cough, dysuria, aggravation of respiratory symptoms and rash.
Ipratropium bromide is a muscarinic antagonist, bronchodilator, and isopropyl salt of AtropineN.
Ipratropiumbromide and Formoterol combined partly to protect the lungs from chronic inflammation and enlarge the lungs, reducing neutrophils by inhibiting activity via MMP-9. Ipratropiumbromide(1nM) significantly increased the calcium bromide, reduced forward scattering and increased annexin-V binding. After the Ipratropiumbromide treatment, hemolysis increased slightly but significantly. Ipratropiumbromide causes suicidal red blood cell death or eryptosis, primarily due to calcium stimulation.
Ipratropium dry powder inhalation (DPI) was an effective bronchodilator in resting horses at a dose of 2400 mg/horse, with little effect on upper airway caliber during recovery. In cadmium-treated rats, Ipratropium significantly attenuated parenchymal inflammatory cell inflow and observed crowded associated lung lesions. Ipratropium partially protects the lungs from inflammation by reducing neutrophil infiltration. In guinea pig tracheal smooth muscle, Ipratropium is an antagonist that inhibits the prebound muscarinic inhibitory receptor of the lung parasympathetic nerve. Ipratropium has also been shown to be a potent antagonist post-binding to muscarinic inhibitory receptors. Ipratropium reduces maximum changes in chest pressure and increases dynamic compliance (Cdyn) in tidal respiration (incremental Pplmax) and pulmonary resistance (RL) in horses.