71989-38-3 Fmoc-L-Tyr(tBu)-OH

71989-38-3 Fmoc-L-Tyr(tBu)-OH  is one of intermediates of Oxytocin.

Pharmacological effects

1. Excitement of uterine smooth muscle Small doses can enhance the rhythmic contraction of the uterine body at the end of pregnancy, the nature of the contraction is similar to that of normal delivery, to promote the smooth delivery of the foetus. When the dose is increased, the effect is strengthened and even produces persistent tonic contraction, which may cause foetal asphyxia. Estrogen can increase the sensitivity of the uterine smooth muscle to the contraction of the uterus, while progesterone can reduce the sensitivity.

2. Other High-dose contraction of the uterus can directly dilate the blood vessels, causing a drop in blood pressure, reflexively cause the heart rate to accelerate, increased cardiac output, and antidiuretic and lactation effects.

Clinical application

1. Hypnosis and induction of labour Small doses of hysteronin are used for hypnosis in women with normal foetal position, no obstruction of the birth canal and weak contractions to promote labour. For stillbirth, overdue pregnancy, or pregnant women with heart disease, tuberculosis and other diseases, need to interrupt the pregnancy in advance, can be used to induce labour.

2. Post-partum haemostasis can make the uterus contracted, compression of blood vessels in the uterine myometrium to stop the haemostasis, but the effect of time is short, should be added with ergot preparation, so that the uterus to maintain contraction.

3. Shortening of the third stage of labour High concentration of uterine contractions to promote the placenta detachment, to shorten the third stage of labour to reduce the number of Postpartum uterine bleeding.