75932-02-4 N-α,N-ε-di-Fmoc-D-lysine

Double-protective amino acids mainly include D-lys-OH containing side chain amino groups and side chain-containing chain protection of L-Rag-OH. For the A-A-amin group, the FMOC protection strategy is still adopted, and the second uncle of the two-carbonate is used in the side chain. Tibon is introduced into a piping oxygenyl group to protect Fu Fu 5 ~ Sulfidal to protect. Because there are many synthesis steps for these two amino acids, the main response to the main response steps perform single factor optimization experiments. The protection of D-LYS-OH mainly considers the time that affects the generation of copper fits the temperature, and the time to take off copper. The protection of L-Rag-OH mainly considers the preparation of Z-RG-OH. At the time, the temperature of the Z-L-Rag (PBF) -OH ring of ammonia salt, as well as the amount of catalyst when the hydrogen is lined with Z,

The pressure, temperature and time of the reaction have obtained a good output through optimization experiments.

During the reaction process, the TL.C detection reaction process is mainly adopted, and the crystallization conditions of the product are optimized.

The purity of the product was measured by high -efficiency liquid chromatography, and the purity of the product reached more than 95.0%. In addition to the general physical constant signs, also including infrared spectrum, mass spectrum or hydrogen spectrum.