Common amino protection methods

1. Cbz
Benzyloxycarbonyl (Cbz) Protected Amino
Deprotection of N-benzyloxycarbonyl (Cbz)
Commonly used reagents - CbzCl

2. Alloc
Allyloxycarbonyl (Alloc) protected amino group

3. Trifluoroacetyl
Trifluoroacetyl protected amino group

4. Benzyls
p-methoxybenzyl (PMB) protected amino group
2,4-dimethoxybenzyl protected amino group
Benzyl protected amino
Deprotection of benzyl-protected amino group
N-Bn debenzylation by chloroformate method

5. Pht (phthaloyl)
Phthaloyl (Pht) protected amino groups
Deprotection of phthaloyl-protected amino group

6. Benzenesulfonyl
Nitrobenzenesulfonyl protected amino group
p-toluenesulfonyl (Tos) amino protection

7. Trt
Trityl protected amino
Deprotection of trityl-protected amino group

8. Boc
Tert-butoxycarbonyl protected amino group
Deprotection of N-tert-butoxycarbonyl
Oxalyl Chloride De-Boc

9. Fmoc
Wat methoxycarbonyl protected amino group
Commonly used reagents - Fmoc-Cl

10. SEM
SEM protected amino

11. Others
Acetamide protected amino group
Clauson-Kaas pyrrole synthesis reaction (this reaction can be used as a method to protect amino groups, can replace double Boc protection, and is more stable)
Commonly used reagents - benzyl (chloromethyl) ether
Commonly used reagents - (chloromethyl) methyl ether [MOMCl]
Carbamate Protection